Nanogold for the treatment of zoonotic cutaneous leishmaniasis caused by Leishmania major (MRHO/IR/75/ER): An animal trial with methanol extract of Eucalyptus camaldulensis

Journal of Pharmaceutical & Health Sciences

مقاله 1، دوره 1، شماره 1، اسفند 2012، صفحه 13-16   

نوع مقاله: Original Article

نویسنده

mehdi mohebali^*

چکیده

This experimental study was conducted to assess of effectiveness of two nanogold concentrations against cutaneous leishmaniasis (CL) caused by Iranian strain of Leishmania major in BALB/c mice model. Cutaneous lesions were experimentally induced by inoculation with Iranian Leishmania major promastigotes (MRHO/IR/75/ER) in 61 BALB/c mice. The infected mice were enrolled to four groups: interventional groups which were treated with two different concentrations of nanogold and two control groups. Nanogold solutions applied topically twice daily for 28 days (N=30) and the results compared with control groups (N=31).The results showed that amastigote number into the lesions, were significantly decreased in interventional groups compared with control groups (p=0.001). Nanogold solutions were also decreased mortality rate in the mice (p=0.003). No statistically difference was found between 40 μg/ml and 0.4μg/ml of nanogold concentrations in amastigote reduction (p=0.648).

کلیدواژه‌ها

Leishmania major؛ Cutaneous leishmaniasis؛ Nanogold؛ BALB/c mice