Apelin: A promising therapeutic target? (Part 1)

Journal of Pharmaceutical & Health Sciences

مقاله 8، دوره 2، شماره 2، خرداد 2014، صفحه 133-138   

نوع مقاله: Original Article

چکیده

Apelin is a recently discovered bioactive peptide, known to be an endogenous high-affinity ligand
for the previously orphan G protein-coupled receptor APJ. Apelin/APJ as a novel signaling pathway
has been shown to play many crucial roles in cardiovascular function, blood pressure regulation, fluid
homeostasis, feeding behavior, obesity, type 2 diabetes mellitus, adipoinsular axis regulation, cell
proliferation, angiogenesis, neuroprotection and thermoregulation. This ubiquitous peptide opens a
new field of research in biology and medicine. In this regard, the aim of this short review is to compile
the evidence for the apelin involvement in modulation of cardiovascular system and introduction of
this new peptidic pathway as a useful drug target in the treatment of cardiovascular diseases in future.

کلیدواژه‌ها

Apelin؛ APJ؛ G-protein Coupled Receptor؛ Heart failure؛ nitric oxide؛ Hypertension؛ Atherosclerosis