SiO2-BaCl2 as a Highly Efficient and Reusable Heterogeneous Catalyst for the One-pot Synthesis of 3,4-dihydropyrimidin-2-(1H)- one/thione Derivatives Under Solvent-free Conditions

Journal of Applied Chemical Research

مقاله 9، دوره 9، شماره 1، فروردین 2015، صفحه 95-101   

نوع مقاله: Research Paper

نویسنده

Farhad Hatamjafari

چکیده

An efficient protocol for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives
via multi-component coupling reaction of aromatic aldehydes, β-ketoester and urea or
thiourea under solvent-free conditions using Silica Supported Barium Chloride as a catalyst
is described. All prepared compounds with melting points, IR,1H NMR and 13C NMR were
identified. High yields, mild conditions, easy availability and reusability were some advantages
of this catalyst. 

کلیدواژه‌ها

3؛ 4-Dihydropyrimidin-2-(1H)-ones/thiones؛ Multi-component reactions؛ Silica Supported Barium Chloride ( SiO2-BaCl2)؛ Solvent-free conditions