One –Pot Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation Reaction Using Nanosized Magnesium Oxide as Heterogeneous Catalyst

Journal of Applied Chemical Research

مقاله 6، دوره 8، شماره 4، دی 2014، صفحه 57-63   

نوع مقاله: Research Paper

نویسندگان

Hakimeh Mirzaee^* ؛ Ahmad Izadyar؛ Abolghsem Davoodnia؛ Hoseyn Eshghi

چکیده

An efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline derivatives have been developed via multi-component one-pot Hantzsch reaction of various aromatic aldehyde, 2 equivalents of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), ethyl acetoacetate and ammonium acetate using nano magnesium oxide as a catalyst in ethanol under reflux condition. Reaction with 4-chlorobenzaldehyde was selected as the model reaction and different conditions for temperature, amount of catalyst and kind of solvent have been studied on it. It was found that 0.03 g catalyst in reflux condition and ethanol as solvent is the optimum condition which resulted in 94% yield. The present approach offers several advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst.

کلیدواژه‌ها

Nano magnesium oxide؛ Polyhydroquinolines؛ Hantzsch method؛ Solid catalyst؛ Dimedone