Trichloroacetic Acid as an Efficient Catalyst for One-pot Synthesis of Highly Functionalized Piperidines via multi-component Reaction

Journal of Applied Chemical Research

مقاله 8، دوره 9، شماره 4، دی 2015، صفحه 81-89   

نوع مقاله: Research Paper

نویسندگان

Nourallah Hazeri^* ؛ Elham Fereidooni

چکیده

Trichloroacetic Acid (TCA) was used as an efficient catalyst for the synthesis of highly
functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic
aldehydes and β-keto esters in MeOH at room temperature. The remarkable advantages
offered by this method are good yields, simple procedure, short reaction times, no need to
column chromatography and an easy work-up. 

کلیدواژه‌ها

Piperidines؛ Trichloroacetic Acid؛ Multi-component reaction؛ β-keto esters