Microwave assisted oxidation coupling of thiols to symmetrical disulfides with tripropylammonium fluorochromate (VI) (TPAFC)

Journal of the Iranian Chemical Research

مقاله 2، دوره 3، شماره 3، اسفند 2010، صفحه 155-160   

نویسندگان

Mohammad Kazem Mohammadi^{* 1}؛ Neda Hasanzadeh¹؛ Shahriare Ghammamy²

¹Islamic Azad University, Ahvaz Branch , Faculty of Science, Ahvaz , Iran

²Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran

چکیده

Tripropylammonium fluorochromate(VI) (TPAFC), is an efficient and new reagent, which is
prepared easily and oxidizes thiols to the corresponding disulfides, quickly. The reactions are
performed cleanly and are controlled to stop at the disulfide stage, without over-oxidation and
side products. Coupling of thiols to their corresponding disulfides, are studied in solution at
room temperature and in solution under microwave radiation. The easy procedure, simple workup,
short reaction times, and excellent yields, are another advantages of this reagent.

کلیدواژه‌ها

thiol؛ Oxidation؛ Coupling؛ Disulfide؛ Tripropylammonium fluorochromate؛ Microwave irradiation

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