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Doulah, Abdolhassan, Mirzaei, Masoud, Nikpour, Mohsen, Farbood, Yaghoub. (1390). Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 4(2), 93-96.
Abdolhassan Doulah; Masoud Mirzaei; Mohsen Nikpour; Yaghoub Farbood. "Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 4, 2, 1390, 93-96.
Doulah, Abdolhassan, Mirzaei, Masoud, Nikpour, Mohsen, Farbood, Yaghoub. (1390). 'Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 4(2), pp. 93-96.
Doulah, Abdolhassan, Mirzaei, Masoud, Nikpour, Mohsen, Farbood, Yaghoub. Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1390; 4(2): 93-96.

Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors

Journal of the Iranian Chemical Research
مقاله 4، دوره 4، شماره 2، شهریور 2011، صفحه 93-96    اصل مقاله (102.8 K)
نویسندگان
Abdolhassan Doulah* 1؛ Masoud Mirzaei2؛ Mohsen Nikpour3؛ Yaghoub Farbood4
1Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz 6134968875, Iran
2Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Mashhad, 91775-1436, Iran
3Department of Chemistry, School of Sciences, Islamic Azad University, Ahvaz Branch, Ahvaz, 6134968875, Iran
4Physiology Research Center and Department Physiology, Medicine Faculty, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran
چکیده
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with
dimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-
e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with
secondary amines in boiling ethanol to afford the related 7-amino derivatives.
کلیدواژه‌ها
1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine؛ Dimethylthio carbamoylchloride؛ pyrimidothiadiazine؛ Cyclocondensation
مراجع
[1] T. Naka, S. Furukawa, Japan. Kokai, 78 31,694 Cl. C07D487/04), 25 Mar 1978, Appl. 76/105, 191,
01 Sep 1976; 10pp [Chem. Abstr., 89 (1978), 109596].
[2] H. Ogura, H. Takahashi, M. Sakaguchi, Nucl. Acid. Res. 1 (1978) s251-s256.
[3] T. Naka, S. Furukawa, Japan. Kokai 78 28,192 (Cl. C07D513/04), 16 Mar 978, Appl. 76/101, 923, 25
Aug 1976; pp [Chem. Abstr., 89 (1978), 59905].
[4] M. Bakavoli, M. Nikpour, M. Rahimizadeh, M.R. Saberi, H. Sadeghian, Bioorg. Med. Chem. 15
(2007) 2120-2127.
[5] M. Bakavoli, H. Sadeghian, Z. Tabatabaei, E. Rezaei, M. Rahimizadeh, M. Nikpour, J. Mol. Model.,
14 (2008) 471-478.
[6] M. Nikpour, M. Mirzaei, Y.-G. Chen, A.A. Kaju, M. Bakavoli, Inorg. Chem. Commun. 12 (2009)
879-882.
[7] M. Nikpour, H. Sadeghian, M.R. Saberi, N.R. Shafiee, S.M. Seyedi, A. Hosseini, H. Parsaee, A.
Taghian, Bioorg. Med. Chem. 18 (2010) 855-862.
[8] M. Rahimizadeh, M. Nikpour, M. Bakavoli, J. Heterocycl. Chem. 44 (2007) 463-465.
[9] M. Bakavoli, M. Nikpour, M. Rahimizadeh, J. Heterocycl. Chem. 43 (2006) 1327-1329.
[10] A. Doulah, M. Nikpour, H. Sadeghian, unpublished data.

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