Cu(II) and Zn(II) complexes with unsymmetrical tetradentate Schiff base ligands: Synthesis, spectral characterization, antimicrobial assay and DNA binding property

Journal of the Iranian Chemical Research

مقاله 1، دوره 5، شماره 4، اسفند 2012، صفحه 197-212   

نویسندگان

Natarajan Raman^{* 1}؛ Rajkumar Mahalakshmi¹؛ Abraham Selvan²؛ Muthusamy Selvaganapathy¹

¹Research Department of Chemistry, VHNSN College, Virudhunagar-626 001, India

²Department of Chemistry, Veltech Hightech, Engineering College, Avadi, India

چکیده

The reaction of copper(II) chloride and zinc(II) chloride with N-(2-methylphenyl)-3-(1'-salicylaldehydene-2'-
imine-ethane)-butanamide(H2L2a) or (MPSB), N-(2-methylphenyl)-3-(1'-(3'-methoxysalicylaldehydene-2'-
imine-ethane)-butanamide (H2L2b) or (MPMSB) and N-(2-methylphenyl)-3-(1'-(2'-hydroxyacetylene-2'-
imine-ethane)-butanamide (H2L2c) (MPHB) leads to the formation of a series of new complexes and they
have been characterized by the spectral and analytical techniques. For the complexes [CuL2a-c] and [ZnL2ac],
the central metal ion is coordinated to two azomethine nitrogen atoms and one phenolic oxygen atom of
the aromatic aldehydes as well as 2-hydroxyacetophenone and enolic oxygen atom of the 2'-
methylacetoacetanilide. DNA binding studies reveal the stronger binding capability of the present copper(II)
complexes, confirmed by the absorbance, cyclic voltammetry, differential pulse voltammogram and
viscometric studies. Similarly, remaining complexes do the same in the ligand field with less binding
constants. In addition, fungistatic and bacteriostatic activities of both ligands and complexes have been
evaluated. copper(II) complexes have shown the most significant activities.

کلیدواژه‌ها

Schiff base؛ Copper complexes؛ DNA binding؛ Cyclic voltammetry؛ Viscometry

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