A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition

Journal of Chemical Reactivity and Synthesis

مقاله 2، دوره 1، شماره 1، مرداد 2011، صفحه 9-15   

نوع مقاله: Research Article

نویسندگان

Ali Ezabadi^* ؛ Fatemeh Tosan

Department of Chemistry, Faculty of Sciences, Islamic Azad University, Central Tehran Branch, Sanat Square, Iran

چکیده

An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.

کلیدواژه‌ها

Hantzsch 1؛ 4 – dihydropyridines؛ PEG-400؛ Three-component reaction؛ catalyst-free؛ Aldehydes؛ ethyl acetoacetate؛ ammonium acetate