Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines

Journal of Chemical Reactivity and Synthesis

مقاله 3، دوره 1، شماره 1، مرداد 2011، صفحه 16-20   

نوع مقاله: Research Article

نویسندگان

Abdolhassan Doulah^{* 1}؛ Hamid Sadeghian²

¹Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz

²Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

چکیده

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.

کلیدواژه‌ها

1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine؛ dimethylthiocarbamoylchloride؛ pyrimidothiadiazine؛ 15- lipoxygenase