Synthesis of imidazo[2,1-b]thiazole-3-carboxylate through the reaction of thiohydantoins and ethylbromopyruvate

Journal of Chemical Reactivity and Synthesis

مقاله 2، دوره 1، شماره 4، مرداد 2011، صفحه 11-14   

نوع مقاله: Research Article

نویسندگان

Nasimeh Zarei^* ؛ Mohammad Mehdi Ghanbari؛ Marzieh Jamali؛ Mahboobeh Kiamarsi؛ Pegah Mohagheghzadeh

Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

چکیده

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate.  These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions

کلیدواژه‌ها

Imidazo[2,1-b]thiazole؛ Thiohydantoin؛ Ethylbromopyruvate؛ anticancer؛ Thioxoimidazolidin