Condensation of thiohydrazide analogues with 4-bromo-3, 6-dichloropyridazine: an efficient rout to pyridazino[4, 3-e][1, 3, 4]thiadiazines.

Journal of Chemical Reactivity and Synthesis

مقاله 8، دوره 2، شماره 3، مرداد 2012، صفحه 62-70   

نوع مقاله: Research Article

نویسندگان

Mohsen Nikpour^* ؛ Mahsa Salehpoor Kiani

Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz 6134968875, Iran

چکیده

Some new 3-(alkylsulfanyl)- 7-chloro-1-phenyl-1H-pyridazino [4,3-e][1,3,4]thiadiazine were synthesized  by treatment of the alkyl-2-phenylhydrazinecarbodithioates with 4-bromo-3,6-dichloropyridazine in alkaline acetonitril. Orientation of the reaction has been determined by X-Ray crystallography technique. The chlorine atom on the number 7 position of these products was replaced by secondary amines in reflux condition.

کلیدواژه‌ها

4-bromo-3؛ 6-dichloropyridazine؛ nucleophilic displacement؛ Mass Spectroscopy