One-Pot Synthesis of Phenytoin Analogs in soilution Conditions

Journal of Chemical Reactivity and Synthesis

مقاله 6، دوره 3، شماره 2، شهریور 2013، صفحه 53-62

نوع مقاله: Research Article

نویسندگان

Alireza Kiasat^* ؛ Maryam Nikmanesh

Department of Chemistry , Shahid Chamran University , Ahvaz , Iran

چکیده

phenytoine derivatives were synthesized , via the pinacol condensation with the
reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea
in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at
room temperatures. The reaction was completed at short reaction times (approximately
15min) and pure products were obtained with high yields (81-94%).

کلیدواژه‌ها

Phenytoin؛ Green Chemistry؛ solvent free؛ Synthesis؛ Grinding