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Azizian, Javad, Miri, Ramin, Mohammadi, Mohammad Kazem. (1393). Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 4(1), 20-29.
Javad Azizian; Ramin Miri; Mohammad Kazem Mohammadi. "Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 4, 1, 1393, 20-29.
Azizian, Javad, Miri, Ramin, Mohammadi, Mohammad Kazem. (1393). 'Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 4(1), pp. 20-29.
Azizian, Javad, Miri, Ramin, Mohammadi, Mohammad Kazem. Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1393; 4(1): 20-29.

Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives

Journal of Chemical Reactivity and Synthesis
مقاله 1، دوره 4، شماره 1، شهریور 2014، صفحه 20-29    اصل مقاله (331.97 K)
نوع مقاله: Research Article
نویسندگان
Javad Azizian1؛ Ramin Miri2؛ Mohammad Kazem Mohammadi* 3
1Factually of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.
2Medicinal & Natural Products Chemistry Research Center , Shiraz University of Medical Sciences , Shiraz , Iran
3Factually of science , Ahvaz Branch Islamic Azad University , Ahvaz , Iran .
چکیده
New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the construction of such heterocyclic ring systems.
کلیدواژه‌ها
heterocyclization؛ 5-Bromo-2,4-dichloro-6-methylpyrimidine؛ Pyrimido[4,5-e][1,3,4]thiadiazine؛ Binucleophile؛ Bielectrophile
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