Synthesis of thiadiazine-3,7-diamine derivatives

Journal of Chemical Reactivity and Synthesis

مقاله 3، دوره 4، شماره 1، شهریور 2014، صفحه 45-54   

نوع مقاله: Research Article

نویسندگان

Nima Razzaghi – asl^{* 1}؛ Mohammad Kazem Mohammadi²

¹Department of pharmaceutical chemistry , ardabil university of medical sciences , ardabil , iran

²Factually of Science, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

چکیده

New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines in simple and efficient methods.

کلیدواژه‌ها

heterocyclization؛ 5- bromo- 2,4- dichloro-6- methylpyrimidine؛ 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine؛ phenylthioisothiocyanate