reaction of thiohydantoins and ethylbromopyruvate for Synthesis of imidazo[2,1-b]thiazole 3-carboxylate

Journal of Chemical Reactivity and Synthesis

مقاله 5، دوره 5، شماره 1، شهریور 2015، صفحه 24-27   

نوع مقاله: Research Article

نویسندگان

Nasimeh Zarei^{* 1}؛ Mohammad Mehdi Ghanbari²؛ Marzieh Jamali²؛ Mahboobeh Kiamarsi²؛ Pegah Mohagheghzadeh²

¹Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran,

²Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

چکیده

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions

کلیدواژه‌ها

Imidazo[2,1-b]thiazole؛ Thiohydantoin؛ Ethylbromopyruvate؛ anticancer؛ Thioxoimidazolidin

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