An Efficient and One-pot Procedure for the Synthesis of Chiral Isoxazolidine via Catalytic Highly Enantioselective 1,3-dipolar cycloaddition

Journal of Applied Chemical Research

مقاله 12، دوره 10، شماره 2، مرداد 2016، صفحه 133-141   

نوع مقاله: Research Paper

نویسنده

Mohammad Javad Taghizadeh

چکیده

Synthesis of enantiomerically pure isoxazolidine via an asymmetric 1,3- dipolar cycloaddition reaction of nitrone with electron-deficient dipolarophile was described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendate bis(imine)–Cu(II)triflate complex as catalyst. The reaction mechanism is discussed on the basis of the assignment of the absolute configuration of the cycloadducts.

کلیدواژه‌ها

Asymmetric 1؛ 3-dipolar؛ Chiral auxiliaries؛ Chiral isoxazolidine؛ Nitrone