One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation

Journal of Applied Chemical Research

مقاله 9، دوره 11، شماره 1، فروردین 2017، صفحه 107-113   

نوع مقاله: Research Paper

نویسندگان

Mohsen Sargordan Arani^* ؛ Behrooz Mirza؛ Mohammad Moghanlou

چکیده

Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thiourea .H3 BO3 , H2 C2 O4 , Me3 SiCl (TMSCl) using as catalyst and compared product yield.Products were characterized with IR, 1 H NMR, 13C NMR and mass spectroscopy

کلیدواژه‌ها

Biginelli reaction؛ Dihydropyrimidinones؛ One-pot synthesis؛ Ethyl cyanoacetate