Antiallergic polyphenols from Citharexylum spinosum

Trends in Phytochemical Research

مقاله 3، دوره 1، شماره 3، آذر 2017، صفحه 129-134   

نوع مقاله: Original Article

نویسنده

Ahmed E. Allam^{* 1، 2}

¹Division of Systematic Forest and Forest Products Sciences, Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University 812-8581, Japan

²Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

چکیده

Three polyphenolic compounds; 1,3,6-tri-O-galloyl-β-D-glucopyranose (TGG) (1), methyl gallate (2) and hydroxyquinol (3) have been isolated from the aerial parts of Fiddlewood Citharexylum spinosum L. The structure of the isolated compounds have been established on the basis of spectroscopic methods in addition to comparison with literature data. These compounds in addition to the methanol extract were tested against their antiallergic activity through inhibition of β-hexosaminidase enzyme. It was noticed that all tested compounds and methanol extract have good inhibition for β-hexosaminidase release without affecting the cell viability where the production of β-hexosaminidase was decreased to about 69%, 60% and 56% by compounds (1), (2) and (3) respectively. The antiallergic activity of Fiddlewood has been reported for the first time.

کلیدواژه‌ها

Anti-allergic activity؛ β-Hexosaminidase enzyme؛ Citharexylum spinosum L؛ Polyphenolic compound

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