Solvent Free Synthesis of tetra alkyl- phenyl-1H-pyrimido[4,5-e][1,3,4]Thiadiazine-3,7-diamines

Journal of Chemical Reactivity and Synthesis

مقاله 4، دوره 7، شماره 2، شهریور 2017، صفحه 25-35   

نوع مقاله: Research Article

نویسنده

Mohammad Hosein Farjam^*

Department of Chemistry, Firuzabad Branch, Islamic Azad University, Firuzabad, Iran.

چکیده

New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine  were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate  and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines  in simple and efficient methods. 

کلیدواژه‌ها

heterocyclization؛ 5- bromo- 2,4- dichloro-6- methylpyrimidine؛ 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine؛ phenylthioisothiocyanate