Synthesis of Some Quinazoline Derivatives Functionalized with3-Heterocycles Side Chain

Journal of Chemical Reactivity and Synthesis

مقاله 5، دوره 7، شماره 2، شهریور 2017، صفحه 36-52   

نوع مقاله: Research Article

نویسندگان

Heba E. Hashema^{* 1}؛ Magdy M. Hemdanb²؛ Ahmed S.A. Youssef²؛ Fatma A. El-Mariaha¹

¹Department of Chemistry, College for Girls, Ain Shams University, Helioplis, Cairo 11457, Egypt

²Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt

چکیده

Utilization of benzoxazinone for synthesis quinazolinone derivatives with 3-heterocycle side chain. treatment of benzoxazinon 1 with cyano acetohydrazide or thionocarbohydrazide gave the quinazolinone derivatives 2 or 12. quinazolinone 2 has been utilized as synthon for new  pyridinone, oxazet, thiazole, thiazolidinone and quinazolinone derivatives. Thiosemicarbazide and thiosemicarbazone derivatives are synthesized from quinazolinone 12 by different route. The structures of the new compounds were established on the basis of IR, ¹HNMR, mass spectral data, and elemental analysis.

کلیدواژه‌ها

quinazolinone؛ oxazet؛ thiazole؛ thiazolidinone؛ tetrazine؛ thiosemicarbazone