Evaluation of Chronic and Acute Effects of Gabapentin on Passive Avoidance Learning Process in Mice

Journal of Chemical Health Risks

مقاله 5، دوره 4، شماره 3، آبان 2014   

شناسه دیجیتال (DOI): 10.22034/jchr.2018.544073

نویسندگان

Hormoz Ayromlou^{* 1}؛ Nooshin Masoudian²؛ Naser Ahmadi-Asl³؛ Parisa Habibi³؛ Nahid Masoudian⁴؛ Sasan Andalib¹؛ Maria Yazdani²؛ Hossein Akbari²

¹Neurosciences Research Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

²Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

³Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

⁴Department of Biology, Collage of Basic Sciences, Damghan Branch, Islamic Azad University, Damghan, Iran

چکیده

Gabapentin (GBP) is one of the new antiepileptic drugs (AEDs) applied extensively in neurology and psychiatry. The advantage of new AEDs includes newer mechanism of action, broad spectrum of anti-seizure effects, lesser drug interactions and fewer side effects. GBP is a cyclized analogue of GABA but it does not interact with GABA receptors, nor does it inhibit GABA uptake or prevent the degeneration of GABA. Restricted studies have been performed on acute and chronic effects of GBP on passive avoidance (PA) learning and little is known about its chronic phase. Therefore, the aim of the present study was to evaluate acute and chronic effects of GBP on passive avoidance learning in 100 mice (w=30 gr). Ten mg/kg GBP were injected interaperitoneally for assessment of memory in three steps (acquisition, consolidation and retrieval). Shuttle box trial was used for PA task assessment. Retrieval memory was tested 24h after injection, and the results indicated increased Step Through Latency (STL), showing the enhancement of memory. Moreover, in acute phase of PA, GBP enhanced acquisition and retrieval of memory. In chronic phase of PA, GBP showed no effect on memory. The present study suggests that GBP exerted no destructive effects on cognition; however, it improved emotional cognitive performance in mice in PA tasks.

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