Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds

Journal of Chemical Reactivity and Synthesis

مقاله 6، دوره 8، شماره 1، خرداد 2018، صفحه 37-43   

نوع مقاله: Research Article

نویسندگان

Mohammad Hosein Farjam^* ؛ Ramin Rezaei

Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran

چکیده

An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl₂ as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.