A fast, simple and convenient procedure for the synthesis of fused pyrimidinone derivatives by using [Hmim][HSO4] as a green, efficient and reusable catalyst under solvent-free conditions

Iranian Journal of Catalysis

مقاله 5، دوره 2، شماره 4، اسفند 2012، صفحه 173-178   

نویسندگان

Leila Khazdooz^{* 1}؛ Amin Zarei²؛ Abdol R. Hajipour³؛ Nafisehsadat Sheikhan⁴

¹Department of Science, Khorasgan Branch, Islamic Azad University, Isfahan 81595-158, Iran.

²Department of Science, Fasa Branch, Islamic Azad University, Post Box No 364, Fasa, 7461713591, Fars, Iran.

³Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA. Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, IR Iran.

⁴Department of Science, Najafabad Branch, Islamic Azad University, Isfahan, Iran.

چکیده

In the present of methylimidazolium hydrogen sulfate, the synthesis of arylidene heterobicyclic pyrimidinones is studied by condensation of aromatic aldehyde, cyclopentanone, and urea or thiourea. Using solvent-free conditions, non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.

کلیدواژه‌ها

Pyrimidinone؛ Methylimidazolium hydrogen sulfate؛ Bronsted acidic ionic liquid؛ Biginelli-type reaction

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