L-proline catalyzed synthesis of naphthopyranopyrimidines via multicomponent reaction

Iranian Journal of Catalysis

مقاله 6، دوره 5، شماره 1، خرداد 2015، صفحه 41-48   

نوع مقاله: Articles

نویسنده

Seyyedeh Cobra Azimi^*

Young Researchers and Elites Club, Rasht Branch, Islamic Azad University, Rasht, Iran.

چکیده

A green and efficient one pot, three component protocol for synthesis of naphthopyranopyrimidines by cyclocondensation of β-naphthol, aldehyde, and 6-amino-1,3-dimethyluracil using L-proline as a beneficial catalyst with high catalytic activity under solvent-free conditions at 100 °C is described. In this study, several types of aromatic aldehyde, containing electron-withdrawing groups as well as electron-donating groups, were rapidly converted to the corresponding naphthopyranopyrimidine derivatives in good to excellent yields. The present approach offers several advantages such as short reaction times, simple work-up, excellent yields, non-toxicity of the catalyst, and solvent-free conditions.To the best of our knowledge, this is the first report on the synthesis of naphthopyranopyrimidine derivatives using L-proline as a catalyst under solvent-free conditions. The catalysts can be recovered for the subsequent reactions and reused without any loss of efficiency.

کلیدواژه‌ها

L-proline؛ 6-Amino-1,3-dimethyluracil؛ Solvent-free؛ β-naphthol

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