Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity

Iranian Journal of Catalysis

مقاله 3، دوره 5، شماره 1، خرداد 2015، صفحه 15-19   

نوع مقاله: Letters

نویسندگان

Leila Youseftabar-Miri^{* 1}؛ Maryam Rafieirad²

¹Department of Chemistry, Izeh Branch, Islamic Azad University, Izeh, Iran

²Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran

چکیده

The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity.(The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity, i try to submit paper)

کلیدواژه‌ها

Ionic Liquid؛ Henry reaction؛ Oxindole؛ Isatin

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