SFHS: Reusable catalyst for the synthesis of polyhydroquinoline derivatives and its molecular docking studies against tyrosine protein kinase

Iranian Journal of Catalysis

مقاله 1، دوره 5، شماره 1، خرداد 2015، صفحه 1-8   

نوع مقاله: Articles

نویسندگان

Amit Shivajirao Waghmare^{* 1}؛ Tushar Patil²؛ Kailash Kadam³؛ Shivaji Sandu Pandit³

¹Department of Chemistry, PVP College, Pravaranagar, Tal. Rahata-413 713

²Department of Biotechnology,PVP College, Pravaranagar, Tal.Rahata-413 713

³Department of Chemistry, PVP College, Pravaranagar, Tal.Rahata-413 713

چکیده

An efficient synthesis of polyhydroquinoline derivatives is achieved via Hantzsch condensation reaction between aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of catalytic amount of SFHS in ethanol. This method gives remarkable advantages such as shorter reaction time, simple workup procedure and good to excellent yields. Furthermore the catalyst can be recovered conveniently and reused efficiently. To analyze potential anticancer activity, synthesized derivatives were docked to tyrosine protein kinase (1YJ) against 4ST and PTR binding sites.

کلیدواژه‌ها

Polyhydroquinoline derivatives؛ Multicomponent reaction؛ Silica supported ferric hydrogen sulphate؛ Molecular docking

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