An efficient and convenient synthesis of quinazoline derivatives catalyzed by cyanuric chloride in water

Iranian Journal of Catalysis

مقاله 8، دوره 6، شماره 4، آذر 2016، صفحه 363-368   

نوع مقاله: Articles

نویسندگان

Mahshid Hossaini؛ Reza Heydari^* ؛ Malek Taher Maghsoodlou

Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.

چکیده

In this work, an eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones was developed by condensation reaction of benzylic and heterocyclic aldehydes with 2-aminobenzamide in the presence of catalytic amounts of cyanuric chloride (2,4,6-trichloro-1,3,5-triazin) as an available and inexpensive organo-catalyst under aqueous media as a green conditions. The new compounds characterized by IR, ¹HNMR, ¹³CNMR, Mass spectrometry, and CHN elemental analysis. Excellent yield, clean reaction media, simple workup and easy purification are advantages of this methodology.

کلیدواژه‌ها

Cyanuric Chloride؛ Organo-catalyst؛ Quinazoline؛ green chemistry؛ Aldehyde؛ Water

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