Morpholinium glycolate as an efficient and reusable catalyst for the synthesis of bis(pyrazol-5-ol) derivatives under solvent-free conditions

Iranian Journal of Catalysis

مقاله 1، دوره 8، شماره 2، شهریور 2018، صفحه 73-80   

نوع مقاله: Articles

نویسندگان

Mohd Akmal Shaikh¹؛ Mazahar Farooqui²؛ Syed Abed^{* 3}

¹Post Graduate and Research Centre, Maulana Azad College, Aurangabad-431001(M.S), India.

²Dr. Rafiq Zakaria College for Women, Aurangabad-431001 (M.S), India.

³Government College of Arts and Science, Aurangabad- 431001 (M.S), India.

چکیده

In this paper, an environmentally benign access to synthesize Bis(pyrazol-5-ol) derivatives was developed through the one pot pseudo five component condensation reaction of phenyl hydrazine with ethyl acetoacetate, and different aryl/heteroaryl aldehydes using morpholinium glycolate as the homogeneous reusable catalyst under solvent-free conditions at 80 °C. Further, the ionic liquid was prepared and characterized by FT-IR, ¹HNMR, ¹³CNMR and TG-DTG techniques. The present synthetic protocol offers excellent yields of the products, short reaction times, clean and simple work up, reusability of catalyst up to five runs, a significant reduction in cost, and eco-efficient alternative to the existing methods.

کلیدواژه‌ها

Bis(pyrazol-5-ol)s؛ Morpholinium glycolate؛ Ionic Liquids؛ Homogeneous catalyst

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