A simple and green approach for the synthesis of substituted dihydro-2-oxypyrroles catalyzed by nano-Fe3O4@SiO2/SnCl4 superparamagnetic nanoparticles

Iranian Journal of Catalysis

مقاله 2، دوره 9، شماره 1، خرداد 2019، صفحه 11-19   

نوع مقاله: Articles

نویسندگان

Bi Bi Fatemeh Mirjalili^{* 1}؛ Reza Araqi¹؛ Seyed Ahmad Mohajeri²

¹Department of Chemistry, College of Science, Yazd University, Yazd, P.O. Box. 89195-741, I. R. Iran.

²Pharmaceutical Research Center, School of pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

چکیده

In this work, an efficient and green procedure for the synthesis of dihydro-2-oxypyrroles has been developed. One-pot four-component condensation reaction of aniline derivatives (2 mmol), dialkyl acetylene dicarboxylate (1 mmol), and aldehydes ( 1 mmol) was done in ethanol at 65 °C in the presence of nano-Fe₃O₄@SiO₂/SnCl₄ as a magnetically reusable heterogeneous acid catalyst. The obtained dihydro-2-oxypyrroles were purified without any chromatography techniques. The structure of obtained pure products was identified by physical properties and spectroscopic data such as FT-IR, ¹H NMR, ¹³C NMR and mass spectroscopy. This protocol consistently has the advantages of excellent yields, short reaction time, simple workup, recyclability of the catalyst up to six runs without appreciable loss of activity.

کلیدواژه‌ها

Dihydro-2-oxypyrroles؛ Fe3O4@SiO2/SnCl4؛ Heterogeneous acid catalyst؛ Magnetic catalyst؛ Dialkyl acetylene dicarboxylate

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