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Goswami, S., Kiran, K., Panda, A. B., Sharma, P. P., Mahapatra, S. K., Bhoraskar, S. V., Banerjee, I.. (1390). Synthesis of magnetically active interpenetrating polymer network for drug release. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 2(Issue 1), 37-48. doi: 10.7508/ijnd.2011.01.005
S. Goswami; K. Kiran; A. B. Panda; P. P. Sharma; S. K. Mahapatra; S. V. Bhoraskar; I. Banerjee. "Synthesis of magnetically active interpenetrating polymer network for drug release". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 2, Issue 1, 1390, 37-48. doi: 10.7508/ijnd.2011.01.005
Goswami, S., Kiran, K., Panda, A. B., Sharma, P. P., Mahapatra, S. K., Bhoraskar, S. V., Banerjee, I.. (1390). 'Synthesis of magnetically active interpenetrating polymer network for drug release', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 2(Issue 1), pp. 37-48. doi: 10.7508/ijnd.2011.01.005
Goswami, S., Kiran, K., Panda, A. B., Sharma, P. P., Mahapatra, S. K., Bhoraskar, S. V., Banerjee, I.. Synthesis of magnetically active interpenetrating polymer network for drug release. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1390; 2(Issue 1): 37-48. doi: 10.7508/ijnd.2011.01.005

Synthesis of magnetically active interpenetrating polymer network for drug release

International Journal of Nano Dimension
مقاله 6، دوره 2، Issue 1، آبان 2011، صفحه 37-48    اصل مقاله (799.97 K)
نوع مقاله: Reasearch Paper
شناسه دیجیتال (DOI): 10.7508/ijnd.2011.01.005
نویسندگان
S. Goswami1؛ K. Kiran1؛ A. B. Panda2؛ P. P. Sharma3؛ S. K. Mahapatra2؛ S. V. Bhoraskar4؛ I. Banerjee* 4
1Department of Polymer Engineering, Birla Institute of Technology, Mesra, Ranchi 835215, INDIA.
2Department of Applied Physics, Birla Institute of Technology, Mesra, Ranchi 835215, INDIA.
3Department of Gynaecology and Obstetrics, Midnapur Medical College, West Medinipur,721101, West Bengal,INDIA.
4Department of Physics, University of Pune, Ganeshkhind, Pune 411007, INDIA.
چکیده
Interpenetrating polymer networks (IPN) were formed involving hydrophobic polybutyl acrylate (PBA) and hydrophilic poly hydroxyethyl acrylate (PHEA). PBA prepolymer was first formed in presence of ferric oxide nanoparticles (<30nm) under continuous stirring through free radical polymerization. 2-Hydroxyethylacrylate monomer premixed with crosslinker and initiator was added to it and the reaction was allowed to continue till the gel was formed. The ferric oxide particles were synthesized using thermal arc plasma technique. The particles were characterized by XRD, TEM. The magnetization was determined by VSM. Magnetic response of the IPN was assured after embedment of the iron oxide particles. The signature of particle embedment in IPN gel bulk was confirmed by FTIR and SEM micrographs. Swelling study in three different pH solutions of 4, 6, 9 showed maximum swelling in alkaline pH (9). In vitro biocompatibility was tested on plant cell as well as on bacteria, E-coli. Variation in crosslink density of the IPN in presence of the iron oxide particles was tested and observed to be affecting the drug loading and/or releasing capability of the network. The drug loading and release test of the IPNs with and without iron oxide nanoparticles has been studied for multivitamins, salicylic acid and acetaminophen drugs. 
کلیدواژه‌ها
Interpenetrating Polymer network؛ Iron oxide؛ Nano particles؛ Cytotoxicity؛ Drug loading؛ Drug release
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