The effect of Policosanol on decrease of cholesterol, triglyceride and the other lipid metabolite levels in blood of Wistar rats

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

مقاله 7، دوره 3، شماره 2، آبان 2012، صفحه 105-110   

نوع مقاله: Original article

نویسندگان

Fatemeh Foroohi^{* 1}؛ Mansor Amraei²؛ Hadi Zamani³

¹Department of Microbiology, Islamic Azad University, Quds Branch, Tehran, Iran;

²Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;

³Department of Biology, Islamic Azad University, Quds Branch, Tehran, Iran;

چکیده

Background & Aim: Policosanol is a component from main alcohol groups with long-chain that extracted from cane sugar. In the present research, the effect of policosanol was investigated on decrease of lipid metabolite levels in blood of hypercholesterolemia rats.
Experimental: A number of 32 male Wistar rats race with average weight of 250 g was divided into four groups including negative control group (n=8) that had normal diet, positive control and experimental groups I and II (n=8) with high cholesterol diet of 2% cholestroled, and respectively they received placebo and policosanol with concentrations 0.25 and 0.5 mg/day. After four weeks, following the treatment of animals and bloodletting, the biochemical traits such as cholesterol biochemical, triglyceride, and LDL-C and HDL-C factors were measured.
Results & Discussion: The results showed that in experimental group (I) there was a significant decrease (p<0.05) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (p<0.05) in HDL-C compared with control group. In experimental group II, there also was a significant decrease (p<0.01) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (p<0.01) in HDL-C compared with control group.
Industrial and practical recommendations: Policosanol can be an effective component in decreasing the rate of cholesterol, LDL-C and triglyceride and increasing HDL-C.

کلیدواژه‌ها

Policosanal؛ LDL-C؛ HDL-C؛ Cholesterol؛ Triglyceride

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