Nano Al2O3: An efficient catalyst for the multi-component synthesis of Pyrano [2, 3-d] Pyrimidinone derivatives

International Journal of Nano Dimension

مقاله 9، دوره 6، شماره 3، مهر 2015، صفحه 283-287   

نوع مقاله: Reasearch Paper

شناسه دیجیتال (DOI): 10.7508/ijnd.2015.03.008

نویسنده

N. Montazeri^*

Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

چکیده

Pyrano [2,3-d] pyrimidinone derivatives have received considerable interest from the pharmaceutical industry due to their wide range of interesting biological and therapeutic properties. Nano Al₂O₃ was found to be a highly efficient solid acid catalyst for the preparation of pyrano [2,3-d] pyrimidinone derivatives from the reaction of barbituric acid, aryl aldehyde and malononitrile. Al₂O₃ nanoparticles with the average diameter of 15 nm were used four different contents of 10, 15, 20 and 25 mol%. Present methodology offers several advantages, such as high yields, short reaction time, simple procedure with an easy work-up and mild reaction conditions. The products were obtained in high yields under reflux in H₂O:EtOH (1:1). We believe this applicability of nano Al₂O₃ with mentioned advantages makes our method superior over all previous reported methods to the synthesis of pyrano [2,3-d] pyrimidinone derivatives. The structures of the products were characterized by their physical constants and comparison of their melting points with those of authentic samples.

کلیدواژه‌ها

Nano Al2O3؛ Barbituric acid؛ Aryl Aldehyde؛ Malononitrile؛ catalyst