Pre-concentration of Penicillamine using Fe3O4NPS and analysis of it in drug formulations through spectroscopic method

International Journal of Nano Dimension

مقاله 4، دوره 9، شماره 1، اردیبهشت 2018، صفحه 24-31   

نوع مقاله: Reasearch Paper

نویسندگان

Atefeh Mehrabifar¹؛ Ahmad Riahi^{* 2}

¹Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

²Department of Biology, Faculty of Science, Payam Nour University, Tehran, Iran.

چکیده

First, an effective pre-concentration of penicillamine was done via Fe₃O₄NPS. Then, a simple, rapid and sensitive spectrophotometric method is described for the determination of penicillamine by 2, 6-dichlorophenolindophenol (2, 6-DCPIP), as the chromogenic agent in bulk drug and formulations. It produces a bluish green coloured compound with maximum absorbance 610 nm. Beer's law was obeyed in the concentration range 0.005-0.100 ppm with molar absorptivity 1.97 × 103 L/mol/cm and RSD 0.3-0.82%. Statistical comparison of the results with those from the reference method reveals excellent agreement and accuracy and precision was ±0.481 to ±0.33%. This method is also applied on the whole blood and serum samples collected from the confirmed patients. The reaction of penicillamine with 2, 6-DCPIP was confirmed by FTIR and ¹H NMR. The main advantage of 2, 6-DCPIP was its stability as a reagent solution, resulting in reliable and reproducible results.

کلیدواژه‌ها

Fe3O4NPS؛ Magnetic Nanoparticle؛ Penicillamine؛ Spectrophotometry؛ Serum؛ 2, 6-Dichlorophenolindophenol

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