Modification of multi-walled carbon nanotube by p-amino acetanilide for extraction of buspirone drug

International Journal of Bio-Inorganic Hybrid Nanomaterials

مقاله 7، دوره 6، شماره 3، مهر 2017، صفحه 157-164   

نوع مقاله: Research Paper

چکیده

The improvement of medication techniques that causes the reduction of toxicity and enhancement of drug effectiveness enjoys a special significance. Hence, in this research, many attempts have been made to use factored-in carbon nanotube for measurement and determination of the dose of anti-anxiety disorder drugs in human body’s liquids. In the first place, in order to possess more active sites, the multi-walled carbon nanotube (MWCNT) was factored-in by cyanuric chloride. Then, p-amino acetanilide was placed on the absorbent, as a ligand that has an exclusive suitable interaction with the buspirone drug. In order to confirm the synthesized nanostructure, different techniques, including infrared spectrometry (FT-IR), thermogravimetric analysis (TGA), scanning electron microscope (SEM), and energy dispersive spectroscopy (EDAX) were used and the results were analyzed. In order to determine the optimum conditions, the absorption of the drug under pH conditions and optimum time was studied. Finally, under optimum conditions, the absorption of the drug in blood plasma and urine were carried out by high performance liquid chromatography (HPLC).

کلیدواژه‌ها

Buspirone؛ Carbon nanotube, Drug؛ Functionalized؛ HPLC؛ P-amino acetanilide