Simple and efficient Heterocyclization method for Synthesis of new pyrimido thiadiazine-3,7-diamine derivatives

Journal of Chemical Reactivity and Synthesis

مقاله 8، دوره 8، شماره 4، بهمن 2018، صفحه 56-65   

نوع مقاله: Research Article

نویسنده

Masih Golkari^*

Factually of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.

چکیده

New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine  were synthesized via the cyclo condensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate  and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines  in simple and efficient methods.

کلیدواژه‌ها

heterocyclization؛ methylpyrimidine؛ methylhydrazine؛ phenylthioisothiocyanate