Chemical constituents from the leaves and liana of Salacia nitida (Benth.) N.E.Br. (Celastraceae) and their antimicrobial activities

Trends in Phytochemical Research

مقاله 1، دوره 3، شماره 2، شهریور 2019، صفحه 83-90   

نوع مقاله: Original Article

نویسندگان

Brice Mba’ning^{* 1}؛ Joël E. T. Ateba¹؛ Angelbert F. Awantu²؛ Luciana S. Amaral³؛ Gervais M. Happi⁴؛ Beate Neumann⁵؛ Georg Stammler⁵؛ Bruno Lenta⁴؛ Silvère A. Ngouela¹؛ Iran Malavazi⁶؛ Etienne Tsamo¹؛ Norbert Sewald⁷؛ Edson Rodrigues-Filho³

¹Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Po. Box 812, Yaoundé, Cameroon

²Department of Chemistry, Faculty of Science, University of Bamenda, Po. Box 39, Bambili, Cameroon

³Departamento de Química, Universidade Federal de São Carlos, CP 676, 13.565-905 SP, Brazil

⁴Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Po. Box 47, Yaoundé, Cameroon

⁵Inorganic Chemistry, Department of Chemistry, Faculty of Chemistry, Bielefeld University, University str. 25, Bielefeld, Germany

⁶Departamento de Genética e Evolução, Universidade Federal de São Carlos, CP 676, 13.565-905 SP, Brazil

⁷Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Po. Box 100131, D-33501 Bielefeld, Germany

چکیده

One benzophenone, 4′-hydroxy-2,4,6-trimethoxybenzophenone (1) was isolated from the liana and leaves of Salacia nitida (Benth.) N.E.Br., together with n-hexacosane (2), 29-hydroxyfriedelane (3), 3β-friedelinol (4), n-hexacosan-1-ol (5), n-octacosan-1-ol (6), mangiferin (7), β-sitosterol-3-O-β-D-glucopyranoside (8), friedelin (9), 30-hydroxyfriedelin (10), salaspermic acid (11), 22β-epi-maytenfolic acid (12), orthosphenic acid (13), maltose (14), D-mannitol (15), cangoronine (16), 7-hydroxyfriedelane-1,3-dione (17), tingenone (18), pristimerin (19), α-amyrin acetate (20), β-sitosterol (21) and stigmasterol (22), 21-hydroxyfriedelan-3-one (23), abruslactone A (24), and 2α-hydroxypopulnonic acid (25). The structures of the isolated compounds were established by means of spectroscopic analysis. In addition, the structure of (1) was confirmed by its X-ray diffraction. Compounds (1), (7), (10)-(11), (13), (16)-(19) and (25) were evaluated for their antimicrobial activities. Compound (18) showed a significant activity against Staphylococcus aureus (MIC = 23.8 µM) while compounds (11) and (19) exhibited moderate inhibiting effect against Staphylococcus aureus (MIC = 53.8 µM) and Candida glabrata (MIC = 105.9 µM), respectively.

کلیدواژه‌ها

Antimicrobial activity؛ Benzophenone؛ Leaves and liana؛ NMR spectroscopy؛ Salacia nitida (Benth.) N.E.Br؛ X-ray diffraction

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Supporting information final.docx

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