One-pot Three-Component Synthesis of Dihydroquinoxalin-2-amines Containing a Ferrocene unit with the Potential of Biological and Pharmacological Activities

Journal of Applied Chemical Research

مقاله 7، دوره 13، شماره 3، مهر 2019، صفحه 80-86   

نوع مقاله: Research Paper

نویسندگان

Neda Aghaei؛ Nahid Shajari^*

Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran

چکیده

A three-component reaction between 1,2-phenylenediamine, ferrocenecarbaldehyde, and isocyanides in the presence of a catalytic amount of p-toluenesulfonic acid for the synthesis of 3,4-dihydroquinoxalin-2-amine derivatives containing a ferrocene unit is reported. This approach is an effective procedure because the products have a broad spectrum of biological and pharmacological activities such as insecticide, fungicide, herbicide, anthelmintic, antibacterial, antimycobacterial, antiprotozoal, anticancer and antibiotic properties.

کلیدواژه‌ها

Multicomponent reaction؛ Ferrocene carbaldehyde؛ Quinoxaline؛ p-Toluenesulfonic acid