A simple, solvent-free four-component domino synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by copper (II) oxide

Journal of Applied Chemical Research

مقاله 7، دوره 13، شماره 4، دی 2019، صفحه 83-92   

نوع مقاله: Research Paper

نویسنده

Farzaneh Mohamadpour

Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran

چکیده

An eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of copper (II) oxide (CuO) under solvent-free conditions in high yields. The advantages of this one-pot procedure is environmentally friendly, efficient and economic availability of the catalyst, short reaction times, solvent-free conditions and clean reaction profiles.
           
 

کلیدواژه‌ها

1H-pyrazolo [1؛ 2-b] phthalazine-5؛ 10-dione derivatives؛ Copper (II) oxide (CuO)؛ Economical process؛ One-pot synthesis؛ Solvent-free conditions

سایر فایل های مرتبط با مقاله

Farzaneh Mohamadpour-83,.pdf