Electrospinning Nanofibers Gelatin scaffolds: Nanoanalysis of properties and optimizing the process for tissue engineering functional

Journal of Nanoanalysis

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 شهریور 1398

نوع مقاله: Original Research Paper

شناسه دیجیتال (DOI): 10.22034/jna.2019.1871092.1143

نویسندگان

mohammad jalili¹؛ abolfazl mozaffari^{* 1}؛ mazeyar gashti²؛ masoud parsania³

¹Department of Textile Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran

²Research and Development Laboratory, PRE Labs Inc., 3302 Appaloosa Road, Unit 3, Kelowna, British Columbia, Canada

³Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

چکیده

Electrospinning has been recognized as an efficient and simple technique for the fabrication of polymer nanofibers for biofunctionals. Recently, various polymers have successfully been electrospun into ultrafine fibers. Electrospinning is an extremely promising method for the preparation of tissue engineering scaffolds.
In this study, nanofibers gelatin was electrospun at 20% v/v optimized content. To produce gelatin nanofibers optimally, production parameters need to be investigated. In the electrospinning, device (voltage and distance) parameters were determined to be effective; as a result, these parameters were researched and the influences of electrospinning device parameters (voltage & distance) on properties of gelatin nanofibers were evaluated. These parameters affected the diameter size, uniformity, hydrophilicity and thermal degradation of electrospun gelatin nanofibers. All of these properties were examined by SEM, FTIR, CA, BET, XRAY and TGA tests and finally optimum gelatin nanofibers can be used in many applications including cell culture, drug delivery and tissue engineering.

کلیدواژه‌ها

Electrospinning؛ Gelatin؛ Nanofibers؛ Morphology؛ Tissue Engineering