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Aghamoosa, Monir, sabokbar, Azar, Arbabi Bidgoli, Sepideh, Harzandi, Naser, Ghaffari, Solmaz. (1398). Toxicity assays of Silver nanoparticles in different diameter (10,20,40) on fibroblast (L929). نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 9(2), 1150-1158.
Monir Aghamoosa; Azar sabokbar; Sepideh Arbabi Bidgoli; Naser Harzandi; Solmaz Ghaffari. "Toxicity assays of Silver nanoparticles in different diameter (10,20,40) on fibroblast (L929)". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 9, 2, 1398, 1150-1158.
Aghamoosa, Monir, sabokbar, Azar, Arbabi Bidgoli, Sepideh, Harzandi, Naser, Ghaffari, Solmaz. (1398). 'Toxicity assays of Silver nanoparticles in different diameter (10,20,40) on fibroblast (L929)', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 9(2), pp. 1150-1158.
Aghamoosa, Monir, sabokbar, Azar, Arbabi Bidgoli, Sepideh, Harzandi, Naser, Ghaffari, Solmaz. Toxicity assays of Silver nanoparticles in different diameter (10,20,40) on fibroblast (L929). نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1398; 9(2): 1150-1158.

Toxicity assays of Silver nanoparticles in different diameter (10,20,40) on fibroblast (L929)

International Journal of Molecular and Clinical Microbiology
مقاله 1، دوره 9، شماره 2، اسفند 2019، صفحه 1150-1158    اصل مقاله (1.06 M)
نوع مقاله: Research Article
نویسندگان
Monir Aghamoosa1؛ Azar sabokbar* 2؛ Sepideh Arbabi Bidgoli3؛ Naser Harzandi4؛ Solmaz Ghaffari5
1Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj- Iran.
2Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
3Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences ,Tehran Medical Sciences, Islamic Azad University, Tehran- Iran.
4Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj- Iran
5Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran- Iran.
چکیده
Silver nanoparticles (AgNPs) are one of the most important nanoparticles which have various biomedical applications. For example as antifungal, antibacterial, anti-cancer and anti-inflammatory agents. Skin infection caused by Trichophyton rubrum and some opportunistic fungi such as Candida albicans and Aspergillus fumigatus are sometimes difficult to be treat. Although silver nanoparticle has long been used as effective inorganic antifungal agent; the antifungal activity of nano-Ag in different size has not been investigated yet. Anti-cancer and antifungal effects of spherical silver nanoparticles (nano-Ag) were investigated in this study and we decided to determination toxicity of Nano-Ag in different diameters (10, 20 and 40 nm) on L929 mouse fibroblasts. TEM microscope has been used to evaluate nanoparticles size and morphology. Nano-Ag’s toxicity were evaluated by MTT assay [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]. This study showed that the toxicity of Nano-Ag in low concentration (16-32µg/ml) are sustainable and Silver nanoparticle effects are size dependent.
کلیدواژه‌ها
MTT assay؛ Antifungal؛ viability؛ new drug؛ multi –resistant
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تعداد مشاهده مقاله: 248
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