One-pot Synthesis of 2-amino-4H-chromene Derivatives as Potential Antimicrobial Agents using DABCO-CuCl Complex as an Effective Catalyst

Journal of Applied Chemical Research

مقاله 2، دوره 14، شماره 3، مهر 2020، صفحه 19-25   

نوع مقاله: Research Paper

نویسندگان

Bita Baghernejad^{* 1}؛ Samaneh Koosha²

¹Department of chemistry, Payame Noor University, Iran.

²Department of chemistry, Payame Noor University, Iran

چکیده

A  new  and  efficient  synthesis  of  2-amino-4H-chromene  derivativeswhich  have remarkable pharmacological properties  is  developed  by  one-pot  three-component  efficient  reaction  between aldehydes, malononitrile, and α or β-naphthol in MeOH as solvent using DABCO-CuCl complex as an  effective  catalyst  at  room  temperature. The  structures of  synthesized  compounds  were characterized by techniques of IR,1H-NMR, Mass and elemental analysis. This method provides an efficient improved pathway for the synthesis of chromenes in the terms of excellent  yields, short reaction times and reusability catalyst.

کلیدواژه‌ها

Multicomponent reactions (MCRs)؛ DABCO-CuCl complex؛ Chromenes derivatives؛ One-pot synthesis؛ Antimicrobial agents