Mefenamic acid as Environmentally Catalyst for Threecomponent Synthesis of Dihydropyrano [2,3-c]Chromene and Pyrano[2,3-d]Pyrimidine Derivatives

Journal of Applied Chemical Research

مقاله 6، دوره 14، شماره 3، مهر 2020، صفحه 63-73   

نوع مقاله: Research Paper

نویسندگان

Soheila Asadpour Behzadi؛ Enayatollah Sheikhhosseini^* ؛ Sayed Ali Ahmadi؛ Dadkhoda Ghazanfari؛ Mohammadreza Akhgar

Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

چکیده

Pills of Mefenamic acid were  employed as effective catalysts in the three component reaction of aromatic  aldehydes,  malononitrile,  as  well  as  4-hydroxycoumarin  or  barbituric  acid  in  aqueous solution,  using  reflux  conditions  in  order  to  synthesize  derivatives  of  dihydropyrano[2,3-c]chromene and pyrano[2,3-d]pyrimidine, correspondingly. Among the benefits of this technique, higher efficiency, shorter reaction time, along with better reaction indices could be mentioned.

کلیدواژه‌ها

Mefenamic acid؛ Dihydropyrano [2؛ 3-c]chromene؛ Pyrano[2؛ 3-d]pyrimidine