Distribution of antibiotic resistance among Enterococcus spp. isolated from 2017 to 2018 at the University Hospital "Luigi Vanvitelli" of Naples, Italy.

International Journal of Molecular and Clinical Microbiology

مقاله 7، دوره 9، شماره 2، اسفند 2019، صفحه 1197-1204   

نوع مقاله: Research Article

نویسندگان

Biagio Santella¹؛ Veronica Folliero¹؛ Maria Teresa Della Rocca¹؛ Carla Zannella¹؛ Danilo Pignataro¹؛ Giuseppe Greco¹؛ Fortunato Montella¹؛ Antonio Folgore¹؛ Marilena Galdiero¹؛ Massimiliano Galdiero²؛ Gianluigi Franci^{* 3}

¹Università degli studi della Campania Luigi Vanvitelli

²Università degli studi studi della Campania Luigi Vanvitelli

³Università degli Studi di Salerno - Dipartimento di Medicina, Chirurgia e Odontoiatria

چکیده

In the last decade Enterococcus spp. has become one of the most important nosocomial pathogens. The prevalence of multi-resistant strains of Enterococcus faecium and Enterococcus faecalis responsible for hospital-acquired infections is associated with their ability to acquire and share antimicrobial resistance genes contained in Mobile Genetic Elements (MGE). This study investigated the distribution of antibiotic resistance in Enterococcus spp. isolated from clinical patients in the University Hospital "Luigi Vanvitelli" of Naples, Italy. The aim of the present study was to monitor the antimicrobial drug resistance and spread of nosocomial infection, to allow the optimal choice of antibiotic therapy. From January 2017 to December 2018, 351 Enterococcus spp. isolates were collected from different clinical samples, at the University Hospital “Luigi Vanvitelli”. Bacteria identification was made using MALDI-TOF technology (Bruker Daltonics, Bremen, Germany). Susceptibility to 9 antibiotics was tested using BD Phoenix (Becton, Dickinson and Company). Data were analyzed using the statistical software SPSS v.22.0 (IBM SPSS Inc., New York, USA). Among the 351 collected samples, 88 (25.1%) were identified as Enterococcus faecium and 263 (74.9%) were as Enterococcus faecalis. Enterococcus faecalis showed the highest resistance rate to Tetracycline (73,5%) and Erythromycin (88,6%) than the Enterococcus faecium. The Enterococcus faecium has showed increase in resistance rates against Ciprofloxacin and Imipenem. Persistent surveillance of antimicrobial patterns was essential to adopt the empirical treatment guideline to treat infection caused by Enterococcus spp.

کلیدواژه‌ها

Enterococcus؛ Drug Resistance؛ Bacteria؛ Cross Infection؛ Antimicrobial Stewardship