Promoted Preparation of Aminophosphonate and Functionalized Coumarins Derivatives as Key Constituent of Many Pharmaceutical Compounds

Journal of Applied Chemical Research

دوره 14، شماره 4، دی 2021، صفحه 31-39   

نوع مقاله: Research Paper

نویسندگان

Helia Mohammadi؛ Bita Mohtat^* ؛ Mehran Kordtabar^*

Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

چکیده

The reaction  between  trialkyl  phosphites  with  dialkyl  actylenedicarboxylates  in the presence of 2-hydroxyquinoline  (2-quinolinol)  leads  to  β-aminophsphonates derivatives  which  they  have  many applications in medicinal chemistry. When the reaction was performed by triphenylphosphite, a new pyrano quinoline  compounds  were obtained  in  fairly  good  yields. These  compounds also  provide biologically interesting.  All roducts  were  established  by  IR,  NMR  (¹H,¹³C and³¹P),mass spectroscopy and elemental analysis.

کلیدواژه‌ها

β-aminophsphonates؛ Coumarins؛ Trialkyl (aryl) phosphate؛ 2-quinolinol؛ Dialkyl actylenedicarboxylates