A new phenylpropanoid glucoside from Psorospermum tenuifolium Kotschy (Hypericaceae)

Trends in Phytochemical Research

دوره 5، شماره 1، خرداد 2021، صفحه 31-36   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30495/tpr.2021.680493

نویسندگان

Gervais Mouthe Happi^{* 1، 2}؛ Alexis Sylvain W. Mbobda³؛ Marcel Frese²؛ Simeon Fogue Kouam³؛ Jean Claude Tchouankeu⁴؛ Bruno Ndjakou Lenta³؛ Norbert Sewald²

¹Department of Chemistry, Higher Teacher Training College, University of Bamenda, P.O Box 39, Bambili, Cameroon

²Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany

³Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon

⁴Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon

چکیده

A new phenylpropanoid glycoside named psorospermoside (1) possessing an allose unit was isolated from the Psorospermum tenuifolium Hook f. bark extract together with eleven known compounds. Their structures were elucidated using spectroscopic and spectrometric methods including 1D, 2D-NMR, and ESI-MS, as well as by comparison of their data with those reported in the literature. All the isolated compounds were assessed for their cytotoxicity effect on the human cervix carcinoma cell line KB3-1. Emodin (2) and its congener 2-geranylemodin (3) displayed significant cytotoxicity with IC50 values of 11.4 µM and 19.0µM, respectively. Furthermore, the chemotaxonomic significance of the isolated compounds was also discussed.

کلیدواژه‌ها

Psorospermum tenuifolium؛ Phenylpropanoid glucoside؛ Psorospermoside؛ Emodin؛ 2-Geranylemodin؛ Cytotoxicity

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