Synthesis of New Oxazolam Analogues as the Anti-anxiety Drugs

Journal of Applied Chemical Research

دوره 15، شماره 2، مرداد 2021، صفحه 65-72   

نوع مقاله: Research Paper

نویسندگان

Mohammad Javad Taghizadeh^{* 1}؛ Gholam Reza Malakpouri¹؛ Masoumeh Ghalkhani²

¹Department of Chemistry, University of Imam Hossein, Tehran, Iran

²Faculty of Science, Shahid Rajaee Teacher Training University, Lavizan, Tehran, Iran

چکیده

In this research, an efficient synthesis of oxazolam analogues with a number of advantages such as fast  and  cheap  production  procedure  with  great  yields  was  presented.  The  purpose  of  this investigation was to develop a more economical and technically more feasible route to synthesis of oxazolam  analogues.  Aminobenzophenone  was  acylated  to  give  corresponding amides.  The  ring forming  reaction  of  amides  with  the  appropriate  amino  (alcohol  or  thiol)  produced  oxazolam analogues with 83-98 % total yield.The structures of synthesized compounds were characterized by recording their IR,¹H NMR, ¹³C NMR, and mass spectra.

کلیدواژه‌ها

Benzodiazepines؛ Oxazolam analogues؛ Tricyclic compounds

سایر فایل های مرتبط با مقاله

Mohammad Javad Taghizadeh-65-72.pdf

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