Chemical composition of Leplaea mayombensis (Pellegrin) Staner

Trends in Phytochemical Research

دوره 5، شماره 2، شهریور 2021، صفحه 105-109   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30495/tpr.2021.1922669.1197

نویسندگان

Djeukeu Kemmoe Charlie¹؛ Hermine Laure Djomkam Maza¹؛ Kenmogne Kouam Ariane²؛ Sewald Norbert²؛ Wansi Jean Duplex¹؛ Vardamides Juliette Catherine^{* 1}

¹Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon

²Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany

چکیده

One new coumarinolignan, cleomiscosin F (1) along with ten known compounds namely 3,4-secotirucalla-4(28),7,24-trien-21-hydroxy-21,23-epoxy-3-oic acid (2), 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (3),ceramid A (4),ceramid B (5), mayombensin (6),aridanin (7), stigmasterol and β-sitosterol and their glucosides were isolated from the seeds and roots of Leplaea mayombensis (Meliaceae).Thestructures of the compounds were elucidated based on the interpretation of their spectroscopic data. Some of the isolated compounds (3, 4 and 5) were tested in vitro against bacteria strains Escherichia coli, Bacillus subtilis, Pseudomonas agarici, and Micrococcus luteus. Compound 3 displayed good activity against Bacillus subtilis, Micrococcus luteus, and Pseudomonas agarici with MIC values of 1.7, 2.3 and 9.8µM, respectively; while compound 4 showed significant activity against Micrococcus luteus with MIC value of 11.9µM.

کلیدواژه‌ها

Antibacterial activity؛ Coumarinolignan؛ Leplaea mayombensis؛ Minimum inhibitory concentration

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