بررسی اثرات عصاره آبی گیاه شاهی Lepidium sativum بر روی رفتارهای شبه اضطرابی و شبه افسردگی در موش های سوری نر بالغ

فصلنامه زیست شناسی جانوری

دوره 13، شماره 4، شهریور 1400، صفحه 67-77   

نوع مقاله: مقالات پژوهشی

نویسندگان

فاطمه رحیمی اصل¹؛ مریم خسروی^{* 1}؛ رامین حاجی خانی¹؛ جلال صولتی²؛ حسین فهیمی³

¹گروه زیست شناسی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران

²گروه زیست شناسی، واحد گوهر دشت کرج، دانشگاه آزاد اسلامی، کرج، ایران

³گروه ژنتیک، واحد علوم پزشکی، دانشگاه آزاد اسلامی، تهران، ایران

چکیده

اضطراب و افسردگی از شایعترین بیماری­های روانی هستند. استرس اکسیداتیو از جمله  عوامل ایجاد اضطراب و افسردگی است. دانه شاهی دارای خواص ضد التهابی، آنتی اکسیدانی می­باشد. هدف از این تحقیق بررسی اثر عصاره آبی گیاه شاهی بر رفتارهای شبه اضطرابی و شبه افسردگی در موش های سوری نر بالغ است. در این تحقیق از موش های کوچک نر با محدوده وزنی 35-30 گرم استفاده شد. ابتدا حیوانات مورد آزمایش به مدت 2 هفته تحت تیمار با عصاره آبی دانه شاهی با دوز های   200 ،400 و 600 میلی­گرم بر کیلوگرم قرار گرفتند. پس از پایان دوره تیمار، سطوح اضطراب و افسردگی به ترتیب به وسیله دستگاه ماز بعلاوه مرتفع (EPM) و تست شنای اجباری ارزیابی شد. در هیچ یک از گروه­های دریافت کننده عصاره شاهی تغییرات معنی داری در زمان سپری شده در بازوی باز ، تعداد ورود به بازوی باز و فعالیت حرکتی مشاهده نشد. نتایج حاصل از تست شنای اجباری نشان داد که  در حیوانات دریافت کننده عصاره شاهی با  دوزهای 400 و 600 میلی­گرم بر کیلوگرم  زمان شنا و زمان بی حرکتی نسبت به گروه کنترل به ترتیب افزایش  و کاهش معنی داری  داشته است (01/0 p <). یافته های حاصل از این مطالعه اثرات تعدیل کنندگی عصاره دانه شاهی بر رفتارهای شبه افسردگی را نشان داد، اما  این عصاره بر رفتارهای شبه اضطرابی اثرات معنی داری  نداشت.

کلیدواژه‌ها

افسردگی؛ اضطراب؛ شاهی؛ موش سوری

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