Efficient Synthesis of Thiazolo[4,5-d]pyrimidine derivatives without solvent

Journal of Chemical Reactivity and Synthesis

دوره 9، شماره 3، آبان 2019، صفحه 1-8   

نوع مقاله: Research Article

نویسنده

Mohsen Nikpour^*

Department of Chemistry, School of Sciences, Ahvaz Branch, Islamic Azad University, Iran

چکیده

4-Amino-5-bromo-2-substituted-aminopyrimidines were successfully reacted with various isothiocyanates in the alkaline alumina under Microwave irradiation to achieve a group of reported 2- aminothiazolo[4,5-d]pyrimidine derivatives . These compounds also carried out a multicomponent condensation with carbondisulfid and alkylhalides to furnish a group of reported 2- alkylsulfanylthiazolo[4,5-d]pyrimidine derivatives.

کلیدواژه‌ها

pyrimidine؛ thiazolo[4؛ 5-d]pyrimidine؛ 5-Bromo-2؛ 4-dichloro-6-methylpyrimidine؛ 4-Amino-5-bromo-2-substituted-aminopyrimidines